I'm trying to run my graffiti instance on Windows Server 2008 Web edition and IIS 7 with a custom application pool user. If I change my application pool to Network Service, it works fine. I tried to add my custom application pool user to the IIS_IUSRS group. The error I get appears to be a trust issue. My server is running full trust. I don't see anything in process monitor for the registry, file permissions. Nothing shows up in the security event log.
Steve Schofield
Microsoft MVP - IIS